Abstract
Summary One hundred infants under the age of 3 years and suffering from acute respiratory disease were divided into five equal groups. Each group was treated with one of the following therapeutic agents administered orally: 1. Sulfamethazine 0.1 Gm. per pound per day. 2. Sulfamethazine 0.1 Gm. per pound per day plus 30,000 I.V. dipenicillin G dibenzylethylene diamine per pound per day. 3. Chlortetracycline 10 mg. per pound per day. 4. Oxytetracycline 10 mg. per pound per day. 5. Tetracycline 10 mg. per pound per day. Comparison of failure rate, temperature response, and duration of hospitalization did not reveal any significant differences between the five groups. Minor toxic effects such as diarrhea, vomiting, and skin rashes were more frequently observed in groups 3, 4, and 5. Bacteriological studies suggested that sulfamethazine and sulfamethazine plus penicillin were more effective than broad-spectrum antibiotics against pneumococcal infections.
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