A Study of Acute Renal Failure in the Users of Proton Pump Inhibitors

Abstract

Background: Proton pump inhibitors are one of the most common classes of medications that act by inhibitinggastric H+/K+ adenosine triphosphatase via covalent binding to the cysteine residues of the proton pump,they provide the most potent acid suppression available. Lansoprazole, pantoprazole, and dexlansoprazolehave the greatest bioavailability and achieve the highest plasma levels. Rabeprazole is the most acid-labilePPI and therefore the most potent, whereas pantoprazole is the least reactive and therefore the least potentPatients and methods: Research data were collected from Al-zahraa teaching hospital/ Wasit province andMorgan teaching hospital/ Babylon province, they include patients with acute renal failure who used/ usingproton pump inhibitors compared with those do not use proton pump inhibitors to know the probable relationbetween acute renal failure and the use of proton pump inhibitors. Results and discussion: Results showedthat only 30 patients of 120 patients with acute renal failure consult the hospital were PPIs users, this mayrefer to presence of a relationship between proton pump inhibitor and acute Renal failure . Previous studiesin this field referred to a similar relationship, a case reports and a recent case series implicating these drugsin acute interstitial nephritis (AIN) and progression to acute renal failure.