A Study of a Serological Principle for the Separation of Mixtures of Bacterial Species, with Preliminary Application to the Isolation of Typhoid Bacilli from Feces

Abstract

There are few fields of bacteriology which do not offer the difficult problem of isolating pure cultures of a desired bacterial species when it constitutes a minority of the cells in a natural mixture of microorganisms. This problem has stimulated the development of many ingenious methods of enrichment and selective inhibition, each adapted as closely as possible to the requirements of the particular field of inquiry. However, there are many situations, especially among closely related species, in which selective enrichment cannot be