A study at BRIMS hospital for comparing the tolerability of Cilnidipine and Amlodipine in the treatment of hypertension

Abstract

Introduction: Few of the antihypertensive medicine have been withdrawn owing ADRs. Some are serious enough leading to hospitalization or withdrawal of treatment. Objective: To study the tolerability of Cilnidipine and Amlodipine in patients of hypertensive. Materials and Methods: This study was a collaboration between department of Pharmacology and Medicine of Bidar Institute of Medical Sciences (BRIMS), Bidar. Duration of study was for 9 months from May 2018- January 2019. 100 newly diagnosed mild and moderate hypertensive patients of either sex aged between 18-60yrs were included. ADR were noted and compared using parametric test. Significance was defined as P Result: The patients mean age receiving Cilnidipine was 42.98 ± 8.35 and Amlodipine was 44.48 ± 9.03. On comparison of ADRs between Cilnidipine and Amlodipine it is clear that Amlodipine has more ADRs than Cilnidipine. The Comparison of pedal edema between both the groups show a Statistical Significance with p= 0.0003. Conclusion: It can be concluded from our study that Cilnidipine seems to be better than Amlodipine in the management of the hypertensive patients. Keywords: ADRs, Cilnidipine, Amlodipine, Antihypertensive drugs.