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Abstract
Telomeres are repetitive DNA sequences decorated with telomere-specific proteins at the ends of linear chromosomes in eukaryotic cells. The regulation of human telomere length is essential for maintaining genome stability and cellular lifespan, and its dysregulation causes premature aging and cancer. The heterotrimeric CTC1-STN1-TEN1 (CST) protein complex is vital for the timely termination of telomere elongation by telomerase. CST is also required to recruit DNA polymerase α-primase (pol α-primase) to the newly synthesized telomeric G-overhang ssDNA to convert the telomeric ssDNA to dsDNA (known as C-strand fill-in).
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