Abstract
In 1979, Board [1] described a genetic polymorphism of coagulation factor FXIIIA of plasma and platelets (the a2 subunit, FXIIIA). We report linkage and association studies with this new polymorphic gene marker. The family material studied (Oslo-NHIK material) comprises a total of 375 matings with 1295 offspring. This material has been typed in some 40 polymorphic gene marker systems, including chromosome 6 markers PGM3; GLO; HLA-A, B, C, DR; C4A, C4B; C2; and Bf. FXIIIA typing was performed by high-voltage agarose gel electrophoresis followed by passive transfer of protein bands to nitrocellulose sheets. FXIIIA bands were visualized through the use of specific anti-FXIIIA antibody and peroxidase-conjugated anti-IgG antibody. F13A linkage information was obtained in altogether 111 matings. There is linkage between F13A and HLA region genes with maximum lod score 7.60 at a recombination fraction θ = 0.18 in males. Given linkage, the 95% confidence limits are θ = 0.12 and θ = 0.26.
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