A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Julie Bernhardt,S Thomas Carmichael,Nick S Ward,Steven C Cramer,Numa Dancause,Randolph J Nudo,Kathryn S Hayward,Natasha A Lannin,Leonid Churilov,Amanda Farrin,Lara A Boyd,Theresa A Jones,Dale Corbett

doi:10.1177/1747493019879657

A stroke recovery trial development framework: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable

Julie Bernhardt, S Thomas Carmichael + Show 11 more

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https://doi.org/10.1177/1747493019879657

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Journal: International Journal of Stroke	Publication Date: Oct 1, 2019
Citations: 63

Affiliation: Florey Institute of Neuroscience and Mental Health, University of California, Los Angeles, National Hospital for Neurology and Neurosurgery, Université de Montréal, University of Kansas, Monash University, Alfred Health, University of Melbourne, University of Leeds, University of British Columbia, The University of Texas at Austin, University of Ottawa

#Recovery Trial #Rehabilitation Roundtable + Show 8 more

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Abstract

A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.

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