A Streamlined, Green, and Sustainable Synthesis of the Anticancer Agent Erdafitinib.

Abstract

Erdafitinib, an anticancer drug, was synthesized in a three-step two-pot sequence involving ppm levels of Pd catalyst run under aqueous micellar conditions enabled by a biodegradable surfactant. This process features both pot- and time-economies and eliminates egregious organic solvents and toxic reagents associated with existing routes.