Abstract
Abstract Polyvinylidene fluoride (PVDF)/barium titanate (BaTiO3) composites are becoming increasingly attractive in bone repair since it combines the advantage of polymer flexibility and ceramic piezoelectric constant. Herein, silver (Ag) nanoparticles were decorated on polydopamine functioned BaTiO3 (Ag-pBT) by in situ growth. Then the strawberry-like structured Ag-pBT nanoparticles were introduced into PVDF scaffold fabricated by selective laser sintering. On one hand, Ag nanoparticles would act as a conductive phase to enhance the strength of the polarized electric field on BaTiO3, thereby forcing more domains to be aligned in the direction of the electric field and make piezoelectric effect of BaTiO3 fully play in composite scaffold. On the other hand, Ag nanoparticles would attack multiple targets in bacteria by release of Ag+ and production of reactive oxygen species. In fact, the antibacterial activity is highly desirable for bone repair. Results demonstrated that the PVDF/4Ag-pBT scaffold exhibited enhanced piezoelectric properties with output current and voltage increased by 50% and 40% than that of PVDF/pBT, respectively. In vitro cell culture confirmed that the enhanced electric output further promoted cell proliferation and differentiation. Meanwhile, the scaffold presented robust antibacterial activity against E.coli.
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