A strategy for the treatment of lung carcinoma by in situ immobilization of Ag nanoparticles on the surface of Fe3O4 nanoparticles that modified by lignin

Abstract

This work describes an eco-friendly approach for in situ immobilization of Ag nanoparticles on the surface of Fe3O4 nanoparticles that modified by lignin, without using any toxic reducing and capping agents. The structure, morphology, and physicochemical properties were characterized by various analytical techniques such as Fourier transformed infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), inductively coupled plasma (ICP) and vibrating sample magnetometer (VSM). The Fe3O4/Lignin/Ag NPs was proven to be highly efficient nanocatalyst for the acylation of various amines by utilizing acetic anhydride as a reagent in solvent-free conditions with good yields of acetamide products. The nanocatalyst was easily magnetically recovered and recycled 10 times without any significant loss of catalytic activity. The nanocomposite was also explored biologically in the anticancer assays. Exposure of the Fe3O4/Lignin/Ag NPs samples to lung (NCI-H661, NCI-H1563, CALU 1 and ChaGo-K-1) cancer cells resulted in cell death, which was mostly due to necrosis but slightly due to late apoptosis. The green-synthesized Fe3O4/Lignin/Ag NPs induced cell death, suggesting anticancer prospects that may offer new insight into the development of an anticancer nanomedicine.