Abstract
Various pathogenic properties are associated with fibrous minerals, particularly asbestiform materials. The pathogenesis of these effects has been studied and related to various properties of the fibres involved. These properties include the dimensions of fibres as well as their chemical composition. A consideration of the relevant properties shows that, while the various requirements were to some extent conflicting, a fibre in which the potentially undesirable properties are eliminated, or at least minimised, is feasible provided adequate control over dimensions can be achieved. This has been attempted by ICI Ltd in the production of SAFFIL inorganic fibres. The principles incorporated into the fibre design and the animal tests selected to evaluate the biological properties and the results of these tests are presented. The behaviour of SAFFIL fibres is supportive of current theories on the aetiology of toxic properties of fibres.
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