Abstract
We constructed a multifunctional (Fe3O4/nGO)@mSiO2/GQDs drug carrier for loading and microwave-controlled release of an etoposide (VP16) as the anticancer drug. This nanocomposite consisted of magnetic core Fe3O4, microwave-absorbing nanographene oxide (nGO), fluorescent graphene quantum dots (GQDs) and intermediate barrier layer (mesoporous silica). It has a large surface area of 359.8[Formula: see text]m2/g, excellent fluorescence emission and ample magnetic performance of 36.00[Formula: see text]emu/g. After microwave irradiation for 140 s, the temperature of (Fe3O4/nGO)@mSiO2/GQDs nanoparticles rapidly went up to 90∘C. The loading rate of VP16 was as high as 68%, the release rate reached 87% within 280[Formula: see text]min under microwave irradiation. Therefore, the functionalized (Fe3O4/nGO)@mSiO2/GQDs nanoparticles will have potential application for clinical treatment as drug delivery system.
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