Abstract
1. (1) A high degree of resistance to proguanil (paludrine, chlorguanide) has been produced in P. cynomolgi by repeated subeffective treatment. Significant resistance was observed after 6 months and resistance to maximum tolerated doses after 16 months. The resistance was a thousand times as great as that of the original normal strain. 2. (2) Resistance was not diminished by passage through mosquitoes, or by preservation of the blood by freezing. 3. (3) Resistance was shown by the pre-erythrocytic forms and by the gametocytes and early forms in the mosquito as well as by the endo-erythrocytic forms. 4. (4) The proguanil-resistant strain was normally sensitive to sulphadiazine
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