Abstract
Straightforward access to a series of the cytotoxic sphingolipid-derived alkaloids possessing a pyrrolidine unit and a long hydrophobic side chain was accomplished. Two simple carbohydrate chirons, protected d- and l-erythrofuranose, were chosen as the starting material, and [3,3]-sigmatropic rearrangements, a late stage cross metathesis and an intramolecular nucleophilic substitution were involved as the key transformations. The final analogues of natural broussonetines were evaluated for their capacity to alter the proliferation of cancer cells.
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