Abstract
Topical drug application has been widely used to manage skin diseases as well as to treat a variety of local and systemic disorders. To evaluate the efficiency of transepidermal drug delivery, an efficient model is needed to study the process of percutaneous transport. A stochastic model based on Monte Carlo methods and Cellular Automata is presented in this work to study the molecular transport through the stratum corneum of the human skin, which is a typical process in transepidermal drug delivery. To validate the model, an in vitro experiment on percutaneous absorption of radioactive 17beta-estradiol was performed. The simulation results agree with the experimental data. The use and power of the presented approach in studying the process of transepidermal drug delivery were demonstrated.
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