A stochastic model for the movement of a white blood cell

Abstract

We present a stochastic model for the movement of a white blood cell both in uniform concentration of chemoattractant and in the presence of a chemoattractant gradient. It is assumed that the rotational velocity is proportional to the weighted difference of the occupied receptors in the two halves of the cell and that each of the receptors stays free or occupied for an exponential length of time. We define processes corresponding to a cell with 2nß + 1 receptors (receptor sites). In the case of constant concentration, we show that the limiting process for the rotational velocity is an Ornstein–Uhlenbeck process. Its drift coefficient depends on the parameters of the exponential waiting times and its diffusion coefficient depends in addition also on the weight function. In the inhomogeneous case, the velocity process has a diffusion limit with drift coefficient depending on the concentration gradient and diffusion coefficient depending on the concentration and the weight function.