A stochastic model for high-LET response for boron neutron capture therapy (BNCT).

Abstract

There is evidence showing that there is a significant variation in tumor-boron and blood-boron concentrations for individual patients. There also is a wide variation in the size and location of the tumor. This diversity creates a situation in which treatment must be carefully tailored to the specific needs of each patient. Patient treatment planning will require computer modeling of the various radiation transport and interaction processes expected to occur, coupled with a display of the results in easily interpretable form. Such an analytical evaluation will allow the radiation oncologist to select the beam configuration, specify the irradiation field and positions of local thermal neutron shields, establish the optimum time after boron administration to begin irradiation, and specify the duration of irradiation.