Abstract
L-5-Hydroxytryptophan raises serum insulin levels in mice. This can be explained by a potentiating effect of L-5-hydroxytryptophan on insulin release induced by different secretagogues in pancreatic s-cells. Other substrates for aromatic L-amino acid decarboxylase also stimulate insulin release in isolated mouse pancreatic islets. The stimulatory effect can be coupled to increased turnover by the decarboxylase. L-5-Hydroxytryptophan does not stimulate insulin release in islets from hamsters and rats. The net effect of decarboxylase substrates on insulin release is probably the sum of a stimulatory effect of decarboxylation and an inhibitory effect of formed monoamines.
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