Abstract
Pregnane steroids, particularly 3α-hydroxylated metabolites of progesterone, are known to have rapid and profound effects on brain excitability. Recent evidence suggests that the γ-aminobutyric acid (GABA A)-benzodiazepine receptor-Cl − ionophore complex may mediate these actions. The data further suggest that these steroids modulate the complex through a novel site independent of other known sites on the complex. The hypothesis that this site is on the GABA A-benzodiazepine receptor-Cl − ionophore complex is tested in the present study by determining its presence on transiently expressed GABA A-benzodiazepine receptors.
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