Abstract
A new synthetic approach to silylated polyunsaturated halides has been developed, starting from the readily available (1 E,3 E)-1,4-bis(trimethylsilyl)-1,3-butadiene and (3 E)-1,4-bis(trimethylsilyl)-3-buten-1-yne. A simple epoxidation reaction, followed by regioselective α-opening of the epoxide ring by metal halides affords the corresponding halohydrins with a high degree of stereoselectivity. A subsequent β-elimination reaction from these compounds leads to ( Z, E)-dienyl halides and to ( Z)-enyne halides.
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