Abstract
Arenicolide A (1) and B (2), isolated from the large-scale fermentation of the S. arenicola strain CNR-005 in 2007, displayed cytotoxicity toward the human colon adenocarcinoma cell line HCT-116 (IC50 = 30 μg/mL) and three cell lines in the National Cancer Institute. Arenicolide A (1) is a 26-ring macrolide with three conjugated dienes, nine chiral centers, and one side chain, and its molecular formula is consistent with the high-resolution ESI-FTMS data of the [M+Na] peak at m/z 827.4916. Regarding the synthesis of arenicolide A (1), our group published the synthesis of C26C36 fragment of arenicolide A (1) in 2009 and Miyashita group reported another synthesis of C25-C36 fragment in 2010.
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