A Step towards Malaria Vaccine DBP Engagement with DARC of Erythrocyte

Abstract

Plasmodium vivax is causative agent of malaria. In Plasmodium vivax Duffy binding protein (DBP) is most ligand for merozoite invasion of human erythrocyte surface by DARC. Thus, it is most suitable protein for development of vaccine. Initial infection can stop threw malaria vaccine DBP has great role of a family of related proteins found in different malaria species that are found in host cell invasion. There is only reason of malaria diseases in human being is ligand between DBP and DARC. We studied using bioinformatics tool structure which joins DBP to DARC. After many decades of research, there is still zero result ineffective malaria vaccine. We tried to find out a way that target conserved region of DBP to block the PvDBPDARC attachment. Inhibiting of attachment DBP with DARC by monoclonal antibodies or artificial peptide chain same as DBP may lead us a step towards malaria vaccine. Keywords: Plasmodium vivax, erythrocyte, vaccine Cite this Article Arvind Singh, Gaurav Sharma, Nakuleshwar Dut Jasuja. A Step towards Malaria Vaccine DBP Engagement with DARC of Erythrocyte. Research & Reviews: A Journal of Microbiology and Virology. 2017; 7(3): 19–26p.