Abstract
Diagnostic test performance is traditionally evaluated by comparison to a perfect reference standard test assumed to have 100% sensitivity and specificity. Reverse transcriptase polymerase chain reaction (RT-PCR) detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in throat swabs is currently the most common used diagnostic test for coronavirus disease 2019 (COVID-19). Chest computed tomography (CT) has been suggested by some as an alternative test for initial diagnosis1; However, both RT-PCR and CT are imperfect tests for COVID-19 diagnosis with reports suggesting RT-PCR sensitivity to be only 70%1.
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