A statistical comparison of the spatial distribution of ASSR sources across age

Abstract

Event Abstract Back to Event A statistical comparison of the spatial distribution of ASSR sources across age Ehsan Darestani Farahani1*, Jan Wouters1 and Astrid Van Wieringen1 1 KU Leuven, Department of Neurosciences, Belgium Changes in auditory temporal processing may affect speech perception in ageing persons. Temporal processing is mediated by stimuli-induced synchronized activity in the central auditory system. The auditory steady-state response (ASSR) is a non-invasive measure of synchronized neural activity, induced by amplitude modulated (AM) acoustic stimuli. Different brain areas are involved in the generation of ASSRs. In this study we introduce a statistical framework to investigate possible effects of age on the spatial distribution of ASSR sources (generators) in the brain. ASSRs were obtained of young and older persons after presenting AM noises at 4 Hz and 40 Hz, two modulation frequencies that are present in continuous speech. Independent component analysis (ICA) was used as a linear decomposition to separate the brain source signals mixed by volume conduction in electroencephalography (EEG) recordings. An equivalent current dipole was then fitted for each source using a 4-shell spherical head model. The sources with significant responses to the presented modulation frequencies were determined based on Hotelling's T-squared test. The spatial distribution of these components was modeled by a Gaussian mixture model (GMM). Finally, the Kullback Leibler divergence was applied to provide a comparison between the GMM of ASSR sources in young and older persons. The result of the comparison showed a larger difference between young and older persons for 4 Hz ASSR sources compared to 40 Hz ASSR sources. This suggests that advancing age might have a larger effect on the spatial distribution of the 4 Hz ASSR sources compared to the 40 Hz ASSR sources. Acknowledgements This work was supported by the Research Council of KU Leuven through project OT/12/98. Keywords: Independent Component Analysis, Gaussian mixture model, spatial distribution, auditory steady-state response, amplitude modulation Conference: Second Belgian Neuroinformatics Congress, Leuven, Belgium, 4 Dec - 4 Dec, 2015. Presentation Type: Poster Presentation Topic: Methods and Modeling Citation: Darestani Farahani E, Wouters J and Van Wieringen A (2015). A statistical comparison of the spatial distribution of ASSR sources across age. Front. Neuroinform. Conference Abstract: Second Belgian Neuroinformatics Congress. doi: 10.3389/conf.fninf.2015.19.00005 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 Nov 2015; Published Online: 17 Nov 2015. * Correspondence: Mr. Ehsan Darestani Farahani, KU Leuven, Department of Neurosciences, Leuven, 3000, Belgium, e.darestani@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ehsan Darestani Farahani Jan Wouters Astrid Van Wieringen Google Ehsan Darestani Farahani Jan Wouters Astrid Van Wieringen Google Scholar Ehsan Darestani Farahani Jan Wouters Astrid Van Wieringen PubMed Ehsan Darestani Farahani Jan Wouters Astrid Van Wieringen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.