Abstract
BackgroundThe Differential Adhesion Hypothesis (DAH) is a theory of the organization of cells within a tissue which has been validated by several biological experiments and tested against several alternative computational models.ResultsIn this study, a statistical approach was developed for the estimation of the strength of adhesion, incorporating earlier discrete lattice models into a continuous marked point process framework. This framework allows to describe an ergodic Markov Chain Monte Carlo algorithm that can simulate the model and reproduce empirical biological patterns. The estimation procedure, based on a pseudo-likelihood approximation, is validated with simulations, and a brief application to medulloblastoma stained by beta-catenin markers is given.ConclusionOur model includes the strength of cell-cell adhesion as a statistical parameter. The estimation procedure for this parameter is consistent with experimental data and would be useful for high-throughput cancer studies.
Highlights
The Differential Adhesion Hypothesis (DAH) is a theory of the organization of cells within a tissue which has been validated by several biological experiments and tested against several alternative computational models
The estimation procedure for this parameter is consistent with experimental data and would be useful for high-throughput cancer studies
Steinberg formulated the Differential Adhesion Hypothesis (DAH), which states that cells can explore various configurations and reach the lowest-energy configuration
Summary
The Differential Adhesion Hypothesis (DAH) is a theory of the organization of cells within a tissue which has been validated by several biological experiments and tested against several alternative computational models. The development and the maintenance of multi-cellular organisms are driven by permanent rearrangements of cell shapes and positions Such rearrangements are a key step for the reconstruction of functional organs [1]. Steinberg [4,5,6,7] used the ability of cells to self-organize in coherent structures to conduct a series of pioneering experimental studies that characterized cell adhesion as a major actor of cell sorting. The DAH has been experimentally tested in various situations such as gastrulation [8], cell shaping [9], control of pattern formation [10] and the engulfment of a tissue by another one. Some of these experiments have been recently improved to support the DAH with more evidence [11]
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