Abstract
Changes in CA3 pyramidal cell morphology have a significant effect on cell electrophysiology. Models of 16 pyramidal cells with uniform channel distribution were constructed from neuroanatomical data. Somatic injection of current produced distinct and different firing modes: spiking, bursting, and plateauing. Results show that the change in diameter as a function of the branch distance and path length from the soma is an indicator of firing behavior. Spike rate significantly correlated with dendritic length, surface area, bifurcations, terminations, and branch order. We conclude that dendritic morphology can significantly influence the qualitative and quantitative electrophysiological behavior of neurons.
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