Abstract
This paper gives a statistic study on the formation of ABC raspberry vesicles under bulk swelling with DPD simulations. All vesicles formed through a disc wrap-up process, i.e. a disc micelle wraps up to form a vesicle. The lifetimes of the disc micelles before they become vesicles can be characterized as short and long (tfastandtslow). Vesicles formed with tfast have a high loading efficiency and a wide size distribution. Most of them have low membrane permeability. They resist structural deformation under shear due to their high bending rigidity. Vesicles formed with tslow have a narrow size distribution. They are small, and have low loading efficiency. A large portion of them have permeable membranes with low bending rigidity and structural defects. Shear could restructure these vesicles, and hence modify their permeability. Adjusting the repulsion between solvophobic polymers and solvents impacts on lifetimes of disc micelles. A reduction in such repulsion favours tslow. The knowledge obtained can be used to design raspberry vesicles of desired size, loading and cargo release properties.
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