A state-of-the-art review on the application of various pharmaceutical nanoparticles as a promising technology in cancer treatment

Marischa Elveny,Ali Taghvaie Nakhjiri,Afrasyab Khan,Ahmad B Albadarin

doi:10.1016/j.arabjc.2021.103352

Abstract

Recently, rapid advancement in nanomedicine has opened new horizons towards the treatment of disparate types of cancer. Nanomedicine is considered as the science of applying nanoparticles (NPs) for various diagnostic or therapeutic aims. Nanoparticles (NPs) have attracted increasing interest all over the world for the treatment of disparate types of cancer due to their noteworthy properties such as negligible toxicity and great bioactivity. The main objective of this paper is to present a comprehensive review about the potential of various NPs including silver NPs (AgNPs), gold NPs (AuNPs), selenium NPs (SeNPs), titanium oxide NPs (TiO 2 NPs) and iron oxide NPs (FeONPs) to treat tumoral cells, and investigate the molecular interaction at the cellular level. Moreover, different synthesis mechanisms of NPs along with their operational roles in enhancing the efficiency of conventional chemotherapeutic agents and reducing the toxicity are discussed in detail. Finally, future challenges towards the application of NPs in the field of cancer treatment are presented, and appropriate solutions to remove the ambiguities are suggested.

Highlights

Rapid advancement in nanomedicine has opened new horizons towards the treatment of disparate types of cancer
NPs have illustrated superior performance compared to conventional cancer therapeutic agents due to their outstanding characteristics such as designability in different size, bioactivity, tendency of accumulation in tumoral cells and negligible toxicity to the human body
The main objective of this paper is to present a systematic review about the performance of prominent NPs including AgNPs, AuNPs, selenium NPs (SeNPs), TiO2NPs and FeONPs to treat various cancerous cells

Summary

Introduction

Rapid advancement in nanomedicine has opened new horizons towards the treatment of disparate types of cancer. Nanoparticles (NPs) have attracted increasing interest all over the world for the treatment of disparate types of cancer due to their noteworthy properties such as negligible toxicity and great bioactivity. The main objective of this paper is to present a comprehensive review about the potential of various NPs including silver NPs (AgNPs), gold NPs (AuNPs), selenium NPs (SeNPs), titanium oxide NPs (TiO2NPs) and iron oxide NPs (FeONPs) to treat tumoral cells, and investigate the molecular interaction at the cellular level. Future challenges towards the application of NPs in the field of cancer treatment are presented, and appropriate solutions to remove the ambiguities are suggested. Due to the EPRE, nanotechnology has been offered as a suitable platform to synthesize anti-tumor drug delivery (Dai et al, 2017, Zhang et al, 2021)

Objectives

Methods

Conclusion