A State-of-the-art Review on Applications of Different Analytical Techniques for Some ACE Inhibitors

Abstract

Angiotensin converting enzyme inhibitors are being used for controlling acute and chronic high blood pressure which inhibits the angiotensin converting enzyme. The pharmaceutical analysis of drugs requires effective and efficient analytical methods for quality control, as well as pharmacodynamic and pharmacokinetic studies. In this review article, an extensive survey in analytical chemistry journals had been conducted and varied analytical methods developed so far and used for the estimation of some ACE inhibitors in bulk drugs, formulations, and biological fluids have been reviewed. This review covers over sixty reported analytical methods which embrace capillary electrophoresis, conductometry, HPLC, HPTLC, and electrochemical methods. Bestowed applications concern analysis of ACE inhibitors a single component or in multi-component from pharmaceutical formulations and biological samples. The article will help analysts while selecting the crucial parameters in the development of new method for the estimation of ACE inhibitors.