A Standardised Protocol for Evaluation of Anthelminthic Efficacy

John Horton,Simon Brooker

doi:10.1371/journal.pntd.0001010

Abstract

A Standardised Protocol for Evaluation of Anthelminthic Efficacy

Highlights

The concept of targeted or community-wide treatment for soil-transmitted helminths (STHs) is not new, having been initiated originally by the Rockefeller Sanitary Commission in the United States [1,2] and more recently supported by Warren [3] and others some 30 years ago as a feasible approach, it is only in the last 10 years, since the World Health Assembly resolution [4], that helminth control has become a reality
For field monitoring of anthelminthic efficacy, it is essential that standard protocols are employed that have been tested for their sensitivity and ease of implementation
Since the benzimidazoles were introduced for human use some 30 years ago, there have been many studies, mostly looking at efficacy in single sites on a single occasion, the work in Pemba Island, Republic of Tanzania, has looked at longitudinal changes in efficacy as well [7]

Summary

Introduction

The concept of targeted or community-wide treatment for soil-transmitted helminths (STHs) is not new, having been initiated originally by the Rockefeller Sanitary Commission in the United States [1,2] and more recently supported by Warren [3] and others some 30 years ago as a feasible approach, it is only in the last 10 years, since the World Health Assembly resolution [4], that helminth control has become a reality. For field monitoring of anthelminthic efficacy, it is essential that standard protocols are employed that have been tested for their sensitivity and ease of implementation. Since the benzimidazoles were introduced for human use some 30 years ago, there have been many studies, mostly looking at efficacy in single sites on a single occasion, the work in Pemba Island, Republic of Tanzania, has looked at longitudinal changes in efficacy as well [7].

Results

Conclusion