Abstract
We report a case of 72-year-old woman who was hospitalized with vaginal bleeding and abdominal pain. Magnetic resonance imaging showed tumor both in endometrial cavity and ovaries with multiple distant metastasis. Her serum alpha-fetoprotein level was >54000 ng/mL. Total abdominal hysterectomy with bilateral salpingo-oophorectomy, total omentectomy, appendectomy, bilateral pelvic and paraaortic lymph node dissection, a 20 cm ileal resection with ileal anastomosis, metastasectomy were performed and peritoneal washing was obtained. The pathologic diagnosis was endometrial hepatoid adenocarcinoma. Because of her poor medical condition, she received only palliative chemotherapy. After two days of 5-fluorouracil she died within 2 months. Hepatoid adenocarcinomas are extrahepatic neoplasms that exhibit features of hepatocellular carcinoma. It was first reported as gastric neoplasm but is seen in many different organs and its frequency is increasing. To date only 11 cases of hepatoid adenocarcinoma of the endometrium were reported. It has a poor prognosis and there isn’t an effective treatment yet.
Highlights
Hepatoid adenocarcinomas are alpha-fetoprotein (AFP) producing extrahepatic neoplasms which exhibit features of hepatocellular carcinoma (HCC) (1)
Lungs, kidneys, ovaries and many other various organs had been previously described (2), but hepatoid adenocarcinoma of the endometrium is very rare. To our knowledge this is the 12th case of hepatoid adenocarcinoma of the endometrium
Hepatoid adenocarcinomas have been reported in various organs
Summary
Hepatoid adenocarcinomas are alpha-fetoprotein (AFP) producing extrahepatic neoplasms which exhibit features of hepatocellular carcinoma (HCC) (1). Lungs, kidneys, ovaries and many other various organs had been previously described (2), but hepatoid adenocarcinoma of the endometrium is very rare. To our knowledge this is the 12th case of hepatoid adenocarcinoma of the endometrium. A 72 - year-old woman admitted to a local hospital with vaginal bleeding and abdominal pain. She had diabetes mellitus which was on control with oral antidiabetics. The patient had no other medical history of note Her abdominal ultrasonography showed 57x41 mm multiloculated solid mass in right adnexal region and her liver was normal. Pelvic magnetic resonance imaging (MRI) revealed a 4 cm tumor and fluid in endometrial cavity (Figure 1), 8 cm heterogeneous,
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