A stabilized weak measurement sensor for aptamer detection

Abstract

In this study, an aptamer biosensor based on weak value amplification is proposed for the first time. The feasibility, selectivity, robustness, and high detection accuracy of aptamer sensors are verified by the adenosine triphosphate (ATP) detection experiment. The weak measurement system shows high sensitivity to phase changes, corresponding to refractive index changes, attributed to the changes in the spatial configuration of the aptamer nucleic acid chain after specifically capturing the target molecule. As the main energy source in the body, ATP plays an important role in many biological processes, and its detection is of great significance to study cell metabolism, biochemical pathways, and early-stage disease diagnosis. This work provides a new labeling-free detection scheme for aptamer sensors and offers a high-precision and specific detection of small biological molecules based on weak measurement biosensors. The proposed method is of great significance to the development of aptamer sensors and weak value amplification technology.