Abstract
ABSTRACT A simple and highly sensitive spectrophotometric method was developed for the determination of fenoterol hydrobromide in pharmaceutical formulations. The method is based on measurement of the orange-yellow color peaking at 436 nm, produced when the drug is coupled with diazotized benzocaine in triethylamine medium. The method is applicable over the range of 0.5 – 10 μg/ml, with minimum detectability of 3.6 ng/ml (≈ 9.4×10−9 M). The molar absorptivity is 4.61×104 L. mol−1. cm−1. with relative standard error of 0.196%. The proposed method was successfully applied to the determination of fenoterol in its dosage forms; the mean recoveries of 99.61 ± 1.59 and 98.97 ± 1.52 for tablets and aerosols, respectively, were obtained. The results of the proposed method were favorably compared to those obtained by the official and reference methods. No i8543168 was encountered from the co-formulated drug ipratropium bromide, common excipients and alkaline induced degradation product. A proposal of the reaction pathway is presented.
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