Abstract
Transition metal-catalyzed cycloisomerization of 1,6-enynes is a highly effective approach to generating five-membered rings. Among the various catalytic systems developed, the use of chiral ligands in Rh-catalyzed cycloisomerization induced exceptional reactivity and enantioselectivity. In this study, we describe a novel approach to obtained kinds of five-membered rings via Rh-catalyzed cycloisomerization of N-aryl 1,6-enynes, employing a novel spirosilane diphosphine ligand with a significantly enhanced enantioselectivities. Mechanistic experiments and DFT calculations have provided insights into the reaction mechanism.
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