A Spirometry-Based Algorithm To Direct Lung Function Testing in the Pulmonary Function Laboratory

Abstract

To design a spirometry-based algorithm to predict pulmonary restrictive impairment and reduce the number of patients undergoing unnecessary lung volume testing. Two prospective studies of 259 consecutive patients and 265 consecutive patients used to derive and validate the algorithm, respectively. A pulmonary function laboratory of a tertiary care hospital. Consecutive adults referred to the laboratory for lung volume measurements and spirometry. The sensitivity of the algorithm for predicting pulmonary restriction and the cost savings associated with its use. Total lung capacity correlated strongly with FVC (r = 0.66) and showed an inverse correlation with the FEV(1)/FVC ratio (r = - 0.41). According to the algorithm, only patients with an FVC < 85% of predicted and an FEV(1)/FVC ratio >or= 55% required lung volume measurements following spirometry. The algorithm had a high sensitivity for predicting restriction and a high negative predictive value (NPV) for excluding restriction (sensitivity, 96%; NPV, 98%). The diagnostic properties of the algorithm were reproducible in the validation study. Application of the algorithm would eliminate the need for lung volume testing in 48 to 49% of patients referred to the pulmonary function test (PFT) laboratory, reducing costs by 33%. A spirometry-based algorithm accurately excludes pulmonary restriction and reduces unnecessary lung volume testing in the PFT laboratory almost in half.