Abstract
Three genes of the prion protein gene family are expressed in gonads. Comparative analyses of their expression patterns in mice and goats revealed constant expression of PRNP and SPRN in both species and in both male and female gonads, but with a weaker expression of SPRN. By contrast, expression of PRND was found to be sex‐dimorphic, in agreement with its role in spermatogenesis. More importantly, our study revealed that PRND seems to be a key marker of foetal Leydig cells specifically in goats, suggesting a yet unknown role for its encoded protein Doppel during gonadal differentiation in nonrodent mammals.
Highlights
To cite this version: Aurélie Allais-Bonnet, Johan Castille, Maëlle Pannetier, Bruno Passet, Maeva Elzaiat, et al
A specific role for PRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice
To get deeper into the potential role of the prion protein gene family during gonad development, we report the comparative expression profiles of the three members of the prion protein gene family and the comparative localizations of their encoded proteins during ovary and testis development in two different species: goats and mice
Summary
Sho is expressed in the CNS and both Sho and PrP share neuro-protective properties [15]. To get deeper into the potential role of the prion protein gene family during gonad development, we report the comparative expression profiles of the three members of the prion protein gene family and the comparative localizations of their encoded proteins during ovary and testis development in two different species: goats and mice. These data suggest that Prnd may exert a yet unknown specific role in goat foetal Leydig cells
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