Abstract

Chromatin proteins are present in every species across the tree of life and ensure a dynamic structural and functional organization of their genome. The eukaryotic histone proteins H2A, H2B, H3 and H4 form nucleosomes and play a key role in gene regulation. Transcription is regulated via post-translational modifications of histone tails which induce changes in genome architecture. Many archaeal species express homologues of the eukaryotic histone proteins, but lack the functional tails. Also, their structure and function in vivo remains largely unknown.

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