Abstract
The efficient and promising solvent-free method, catalyzed by Sulphated Tin oxide (SO4 2-/SnO2), has been developed for the synthesis of 1,3,5-triarylbenzene and its derivatives. The Bronsted acidic surfactant catalyst facilitates quick results and high yields, offering additional advantages such as easy separation and reusability with almost the same efficiency for subsequent cycles. This protocol involves the self-condensation of three molecules through cyclotrimerization with high chemo-selectivity. The substrate methyl phenyl ketone contains both electronwithdrawing and electron-donating groups, which assemble the target moiety with high and low yields, respectively. The synthesized compounds are evaluated through in silico studies to assess their drug-likeness properties.
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