Abstract
Hypochlorous acid (HOCl)/hypochlorite (OCl−) plays an important role in immune system, while as a major reactive oxygen species (ROS) in living systems, HOCl/OCl− is responsible for some human diseases. Thus it is critical to monitor the change of HOCl in the living cells. In this study, we prepared a novel fluorescent probe BDP-OX based on BODIPY-Dialdoxime for HOCl/OCl− determination, which displayed a remarkable “ratio” fluorescence response towards HOCl/OCl− with a fast response (completed within 15 s). The ratios of emission intensities at 538–589 nm (I538/I589) displayed a large increase from 0.015 to 2.88 with this probe. More importantly, confocal fluorescence imaging with BDP-OX showed separated signals in the presence of HOCl/OCl− in living A549 cells, that indicating BDP-OX have potential biological application prospects.
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