Abstract
A Solution to Aversive Tasting Drugs for Pediatric and Geriatric Patients
Highlights
Medications dissolve in saliva and bind to taste receptors on the tongue giving a bitter, sweet, salty, sour, or umami sensation
Bitter taste is sensed by the receptors on the posterior part of the tongue and umami taste receptors are located throughout the tongue
It has been shown that Phospholipase C (PLC), a major signaling effector of G-Protein Coupled Receptors (GPCRs), and TRPM5 are co expressed with T1Rs and T2Rs and are vital for sweet, amino acid, and bitter taste transduction
Summary
Medications dissolve in saliva and bind to taste receptors on the tongue giving a bitter, sweet, salty, sour, or umami sensation. Umami, and bitter tastes are triggered by the binding of molecules to G protein-coupled receptors on the cell membranes of taste buds.
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