A solution of the“intrinsic problem”of diastereomer method in chiral discrimination

Abstract

Very potent fluorescent chiral labeling reagents for alcohols, (R, R)-and (S, S)-2-(anthracene-2, 3-dicarboximido)cyclohexanecarboxylic acids, were developed. By labeling with them, the enantiomeric discriminations of primary alcohols having a methyl branching at the carbon from 2 to 9 by 1H-NMR and from 2 to 16 by HPLC were achieved. Further, HPLC separations of all four optical isomers of methyl branched secondary alcohols and enantiomers of 9-nonadecanol were also achieved.