Abstract
A beta detecting probe for intraoperative tumour imaging and localisation has been developed. The probe is based on a charge coupled device which detects the particles directly in its sensitive volume. The active area of the device is encapsulated within a carbon-fibre loaded plastic housing 75 /spl mu/m. Images are displayed in real time on a computer screen with a readout frequency of 1 MHz. A study of the effect of dark current on image formation at body temperature has demonstrated a reduction in the signal of /spl sim/55%. The advantage of this device for intraoperative tumour imaging is its minimal sensitivity to the background gamma radiation. This was confirmed using a /sup 18/F source separated from the CCD with a 2 cm perspex block to absorb the positrons. The linearity of the probe was also tested over an activity range of 1-100 /spl mu/Ci. Although the intrinsic resolution of the CCD was measured to be equal to 66 /spl mu/m, the image resolution of the device was <200 /spl mu/m. The sensitivity of the CCD at body temperature was 1120 counts/sec//spl mu/Ci. A preliminary imaging study demonstrates the potential of this device for clinical use.
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