Abstract
A spectrophotometric method for the determination of sulphathiazole (ST) has been developed, based on solid-phase spectrophotometry. The influence of experimental variables on fixation on Sephadex SP C-25 is discussed. The applicable concentration range is 0.10–10.00 mg/l., with a relative standard deviation of 0.62% and a detection limit of 0.02 mg/l. The accuracy and precision of the method are reported. The proposed method has been satisfactorily applied to the determination of sulphathiazole in pharmaceuticals.
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