Abstract
ASPERGILLOSIS IN CLINICAL CONTEXT Aspergillosis is a fungal infection that can assume a broad spectrum of clinical forms depending on immune status and the presence of underlying lung diseases, ranging from allergic bronchopulmonary aspergillosis to aspergilloma and also to the invasive aspergillosis forms that are a major cause of mortality in severely immunocompromised patients. Pulmonary aspergillosis follows the inhalation of airborne conidia of Aspergillus fumigatus, and pre-existing conditions such as pulmonary functional abnormalities such as cystic fibrosis or chronic obstructive pulmonary disease provides a favorable environment for Aspergillus colonization and biofilm formation in the lungs (Zmeili and Soubani, 2007; Ramage et al., 2011). Due to its great importance in clinical context, a better understanding of the process in filamentous growth and biofilm formation can help to manage Aspergillus infection, especially when dealing with resistant strains to current antifungal drugs (Arendrup, 2013).
Highlights
ASPERGILLOSIS IN CLINICAL CONTEXT Aspergillosis is a fungal infection that can assume a broad spectrum of clinical forms depending on immune status and the presence of underlying lung diseases, ranging from allergic bronchopulmonary aspergillosis to aspergilloma and to the invasive aspergillosis forms that are a major cause of mortality in severely immunocompromised patients
Pulmonary aspergillosis follows the inhalation of airborne conidia of Aspergillus fumigatus, and pre-existing conditions such as pulmonary functional abnormalities such as cystic fibrosis or chronic obstructive pulmonary disease provides a favorable environment for Aspergillus colonization and biofilm formation in the lungs (Zmeili and Soubani, 2007; Ramage et al, 2011)
Previous studies with cultures of A. fumigatus maintained under static aerial conditions have demonstrated the presence of an extracellular matrix (ECM) on the colony surface of colonial mycelia that acts as cohesive linkage bounding hyphae into a contiguous sheath, and this ECM is absent when the fungus is grown under liquid shake conditions
Summary
ASPERGILLOSIS IN CLINICAL CONTEXT Aspergillosis is a fungal infection that can assume a broad spectrum of clinical forms depending on immune status and the presence of underlying lung diseases, ranging from allergic bronchopulmonary aspergillosis to aspergilloma and to the invasive aspergillosis forms that are a major cause of mortality in severely immunocompromised patients. A commentary on Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus by Shopova, I., Bruns, S., Thywissen, A., Kniemeyer, O., Brakhage, A.
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