A smart band-aid with temperature and reactive oxygen species dual-responsiveness for synergistic mechanical and pharmacological therapy of chronic wounds

Abstract

In this study, a dual-responsive multifunctional band-aid comprising a force-induced shrinkage layer and a drug-treated layer has been developed, characterized by its on-demand drug release. Evaluated through the pig skin the force-induced shrinkage layer facilitates active wound closure by forming stable adhesion to the skin. Afterward, the layer could provide mechanical force simulating the embryonic skin in response to temperature changes. Concomitantly, confronting the increased levels of reactive oxygen species (ROS) at the wound site, the drug-treated layer made of an ROS-responsive hydrogel, promptly releases zinc oxide (ZnO) and catalase (CAT) to exert antibacterial and anti-inflammatory stress effects, ultimately accelerating the healing process of chronic wounds. More important, this versatile hydrogel-based band-aid demonstrates remarkable efficacy in both bacteria-infected rat wounds and rat tooth extraction wounds. Overall, the versatility of this approach presents a comprehensive and convenient strategy for the treatment of clinical chronic wounds.