A Small Synthetic Molecule Forms Chloride Channels to Mediate Chloride Transport across Cell Membranes

Abstract

Synthetic ion channels that mimic the functions of natural ion channels are of great interest in chemistry, biochemistry, biology, and materials science. In this paper, we present a novel small synthetic molecule that self-assembles to form chloride channels in lipid bilayers. This compound is the smallest molecule known to form potent synthetic chloride ion channels. It can also partition into plasma membranes of living cells and therein increase anion permeability. This compound has the potential to become a novel lead compound for the treatment of human diseases associated with Cl- channel dysfunctions.