Abstract
Purpose The Glaucoma Stereo Analysis Study, a cross-sectional multicenter collaborative study, used a stereo fundus camera (nonmyd WX) to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients. We compared the associations of each parameter between the visual field loss progression group and no-progression group. Methods The study included 187 eyes of 187 patients with primary open-angle glaucoma or normal-tension glaucoma. We divided the mean deviation (MD) slope values of all patients into the progression group (<−0.3 dB/year) and no-progression group (≧−0.3 dB/year). ONH morphological parameters were calculated with prototype analysis software. The correlations between glaucomatous visual field progression and patient characteristics or each ONH parameter were analyzed with Spearman's rank correlation coefficient. Results The MD slope averages in the progression group and no-progression group were −0.58 ± 0.28 dB/year and 0.05 ± 0.26 dB/year, respectively. Among disc parameters, vertical disc width (diameter), disc area, cup area, and cup volume in the progression group were significantly less than those in the no-progression group. Logistic regression analysis revealed a significant association between the visual field progression and disc area (odds ratio 0.49/mm2 disc area). Conclusion A smaller disc area may be associated with more rapid glaucomatous visual field progression.
Highlights
Glaucomatous optic neuropathy (GON) is characterized by axon degeneration that can be observed as the thinning of the neural rim and enlargement of the cup in the optic nerve head (ONH)
The present study found that a history of systemic hypertension is not a risk factor for visual field progression, since fewer patients in the progression group had systemic hypertension
It is reasonable to assume that prostaglandin (PG) eyedrops are the first choice for administration in glaucoma patients, and PG alone is not associated with disease progression
Summary
Glaucomatous optic neuropathy (GON) is characterized by axon degeneration that can be observed as the thinning of the neural rim and enlargement of the cup in the optic nerve head (ONH). The GSAS previously demonstrated that the DDLS stage obtained through stereoscopic analysis was significantly inversely correlated with the MD and positively correlated with the pattern standard deviation (PSD) [6]. These findings suggest that the DDLS stage reflects the degree of visual field damage that is measured and expressed by the MD and PSD [6]. In the present phase of the GSAS, we examined the relationships between visual field progression and patient characteristics or various ONH parameters
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