Abstract
To the Editor: Penn-Nicholson et al.[1] have suggested using a blood test for diagnosing early tuberculosis. It may be possible, however, to use a skin test to diagnose latent tuberculosis.[2,3] An autoimmune model of tuberculoid leprosy has been developed, using peripheral nerve as antigen. Rabbits were injected with a homogenate of human sensory nerve plus adjuvant. Some of the rabbits developed a state of granulomatous hypersensitivity; i.e. skin testing with a dilute solution of nerve in saline produced an epithelioid cell granuloma, in which the cytoplasm contained dilated rough endoplasmic reticulum filled with an electron-dense product.[4] The antigen is a non-myelin protein, active in doses of 1 μg. The ultrastructural appearances are similar to those in human tuberculoid leprosy. [5]
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