A single-center retrospective study on influence factors on surgical methods in DCIS patients

Abstract

Objective To evaluate the influence factors on surgical methods in DCIS (Ductal carcinoma in situ) patients, and the prognosis of different surgical methods in a 10-year single-center retrospective study. Methods We retrospectively included 1557 DCIS patients who received treatments in our center from Jan. 2006 to Nov. 2016. T tests, Chi-square analysis and logistic regression analysis were used to analyze influence factors on surgical methods. Kaplan-Meier and Log-rank analysis were used to evaluate recurrence-free survival (RFS) and loco-regional recurrence-free survival (LRRFS) in patients with different surgical methods. Results Of the enrolled 1557 DCIS patients, surgical methods included modified radical mastectomy, simple mastectomy (with or without axillary evaluation) and breast conservation surgery (with or without axillary evaluation) . The number of DCIS cases in our center increased (P 15mm (P<0.001) and spontaneous discharge (P<0.001) . Patients with smaller tumor size (≤15mm) and no spontaneous discharge had 4.18-fold and 7.04-fold greater preference for breast conservation surgery, respectively (OR=0.232, P<0.001; OR=0.144, P<0.001) . There were no significant differences in RFS and LRRFS in patients with different surgical methods. Conclusion The evaluation in trends and influence factors of different surgical methods provides basis on surgical precision medicine in DCIS patients. Key words: Ductal carcinoma in situ; Surgery therapy; Breast conservation surgery; Breast reconstruction