Abstract
BackgroundThe efficacy of a single dose of an inactivated bovine respiratory syncytial virus (BRSV) - Parainfluenaza type 3 (PI3) - Mannheimia haemolytica (Mh) combination vaccine, in calves positive for maternal antibodies, was established in a BRSV infection study.ResultsAs expected the single vaccination did not have any effect on the decline of BRSV-specific neutralising or ELISA antibody. The cellular immune system was however primed by the vaccination. In the vaccinated group virus excretion with nasal discharge was reduced, less virus could be re-isolated from lung tissues and the lungs were less affected.ConclusionsThese results indicate that a single vaccination with an inactivated BRSV vaccine was able to break through the maternal immunity and induce partial protection in very young calves. It can be speculated that the level and duration of protection will improve after the second dose of vaccine is administered. A two-dose basic vaccination schedule is recommended under field conditions.
Highlights
The efficacy of a single dose of an inactivated bovine respiratory syncytial virus (BRSV) Parainfluenaza type 3 (PI3) - Mannheimia haemolytica (Mh) combination vaccine, in calves positive for maternal antibodies, was established in a BRSV infection study
There were no increased respiratory rates; the only clinical sign of respiratory disease was coughing of individual animals
BRSV specific immune reaction BRSV specific antibody response All calves had moderate to high antibody titres at the start of the study
Summary
The efficacy of a single dose of an inactivated bovine respiratory syncytial virus (BRSV) Parainfluenaza type 3 (PI3) - Mannheimia haemolytica (Mh) combination vaccine, in calves positive for maternal antibodies, was established in a BRSV infection study. The bovine respiratory syncytial virus (BRSV) has been established as an important viral component in the bovine respiratory disease complex (BRDC) [1]. The virus can act synergistically with other viruses such as the bovine parainfluenza type 3 virus (PI3) or bacteria such as Mannheimia haemolytica (Mh), Pasteurella multocida, Haemophilus somnus and Mycoplasma bovis to cause pneumonia [2]. BRSV fulfils the Koch’s postulates to be recognised as an aetiological agent of pneumonia in calves. Outbreaks of BRSV associated pneumonia typically recur every year [7] and most farms are affected.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
